Thermo Fisher Scientific IKK beta Monoclonal Antibody (10A9B6)
IKK beta 단백질을 표적하는 Mouse 모노클론 항체로, WB, IHC, ICC, Flow, IP 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성. 단백질 G 정제, PBS 버퍼 및 sodium azide 포함. 연구용으로 NF-κB 신호전달 연구에 적합.
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Thermo Fisher Scientific IKK beta Monoclonal Antibody (10A9B6)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–5 µg/mL | View 1 publication |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
| Flow Cytometry (Flow) | 1:10–1:1,000 | - |
| Immunoprecipitation (IP) | 2–5 µg per million cells | - |
| Gel Shift (GS) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10A9B6 |
| Immunogen | Full-length human IKK beta recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537681 |
Product Specific Information
Suggested positive control: Daudi, HeLa, Jurkat, or NIH-3T3.
Target Information
Phosphorylation of serine residues on I-kappa-B proteins by IKK kinases, including IKBKB, marks them for degradation via the ubiquitination pathway, enabling activation of the NF-kappa-B complex.
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential in the NF-kappa-B signaling pathway, activated by stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta forms part of the canonical IKK complex, phosphorylating inhibitors of NF-kappa-B on critical serine residues, allowing polyubiquitination and proteasomal degradation. Consequently, NF-kappa-B translocates to the nucleus to activate genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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