Thermo Fisher Scientific Phospho-TrkA/TrkB (Tyr490, Tyr516) Monoclonal Antibody (H.652.3)
Phospho-TrkA/TrkB (Tyr490, Tyr516) 특이적 단일클론 항체로, 인간·마우스·랫트 반응성. Western blot 및 Immunoprecipitation에 적합. Affinity chromatography로 정제된 액상 형태. 신경영양 인산화 수용체 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:1,000
- Immunoprecipitation (IP): 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H.652.3 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr490 of human TrkA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10980032 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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