Thermo Fisher Scientific Phospho-FLT3 (Tyr842) Monoclonal Antibody (F.447.1)
FLT3 단백질의 Tyr842 인산화 부위를 인식하는 단클론 항체로, Western blot 및 Immunoprecipitation에 최적화되어 있습니다. 인산화 신호전달 연구 및 백혈병 관련 연구에 유용하며, 고순도 Affinity chromatography로 정제된 액상 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.447.1 |
| Immunogen | Synthetic phosphopeptide corresponding to the sequence surrounding pTyr842 of human FLT3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10981188 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
FLT3 (Fms-like tyrosine kinase 3) is a receptor tyrosine kinase involved in hematopoietic cell development. Activation occurs via binding of the FLT3 ligand, leading to receptor dimerization and autophosphorylation. This activates downstream pathways regulating apoptosis, proliferation, and differentiation in bone marrow cells. Mutations causing constitutive activation are associated with acute myeloid and lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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