Thermo Fisher Scientific MNK1 Monoclonal Antibody (E.611.4)
MNK1 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체로, 인간 및 마우스에 반응합니다. Western blot에 최적화되어 있으며, 고순도의 액상 형태로 제공됩니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.611.4 |
| Immunogen | Synthetic peptide corresponding to the sequence of human Mnk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 169 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979171 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The MAP kinase-interacting kinases (MKNK1 and MKNK2) are activated by MAP kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may be involved in responses to environmental stress and cytokines. Expression of active MNK1 and MNK2 mutants in 293 cells reduces cap-dependent translation relative to cap-independent translation. Human Mnk2 shares approximately 94% identity with murine Mnk2 and 71% with human Mnk1. In vitro studies show Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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