Thermo Fisher Scientific BRCA1 Monoclonal Antibody (17F8)
BRCA1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 17F8). Western blot, IHC, ICC, ELISA, IP, ChIP 등에 사용 가능. Human 및 Mouse 반응성. Protein G 정제, PBS 용액 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17F8 |
| Immunogen | Protein fragment expressed in E. coli corresponding to amino acids 762–1315 of BRCA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.55 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557804 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa
- This antibody does not recognize the delta exon 11 splice variant of BRCA1
- The antigen used to produce MA1-23160 has a predicted molecular weight of ~208 kDa
Target Information
BRCA1 (Breast and Ovarian Cancer Susceptibility Protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and acting as a tumor suppressor. It forms part of the BASC (BRCA1-associated genome surveillance complex) and interacts with RNA polymerase II and histone deacetylase complexes. BRCA1 plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects the localization and function of this gene, and several disease-associated variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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