Thermo Fisher Scientific BRCA1 Monoclonal Antibody (6B4)
BRCA1 단백질을 표적하는 Thermo Fisher Scientific의 6B4 모노클론 항체. Western blot, IHC, ICC, IP, ChIP 등 다양한 응용에 적합. 인간 및 마우스 반응성. 단백질 G 정제, 1 mg/mL 농도, PBS 기반 저장용액. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 2 publications |
| Immunoprecipitation (IP) | Assay-dependent | - |
| ChIP assay (ChIP) | Assay-dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B4 |
| Immunogen | BRCA1 protein fragment expressed in E. coli corresponding to amino acids 341–748 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2067334 |
Product Specific Information
- Predicted molecular weight: 220 kDa
- Suggested positive control: HBL100
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and acts as a tumor suppressor. It forms part of the BASC complex (BRCA1-associated genome surveillance complex) with other tumor suppressors and DNA damage sensors. BRCA1 interacts with RNA polymerase II and histone deacetylase complexes, playing roles in transcription, DNA double-strand break repair, and recombination.
Mutations in BRCA1 account for about 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects localization and function, and several disease-associated variants have been identified. A related pseudogene is located on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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