Thermo Fisher Scientific Pan Dux Polyclonal Antibody
Thermo Fisher Scientific의 Pan Dux Polyclonal Antibody는 마우스 Dux 단백질을 인식하는 고품질 항체로, WB 및 ICC/IF 실험에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 핵 내 Dux 단백질 검출에 유용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within mouse Dux aa 520–570 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913297 |
Product Specific Information
- Positive Control: Non-transfected 293T cells lysate, His-tagged Dux transfected 293T cells lysate
- Subcellular Location: Nucleus
Target Information
The double homeobox (DUX) proteins are encoded by 3.3-kilobase repeats found throughout the human genome. The DUX family includes DUX1, DUX2, DUX3, DUX4, and DUX5. Each of these family members, excluding DUX2, contains two homeobox domains; DUX2 contains only one.
DUX1 and DUX5 are identical and share 98% identity with DUX3 and approximately 70% identity with DUX2. The genes encoding DUX5 and DUX3 have additional start sites that result in N-terminal extended isoforms. The homeodomains found in DUX5 and DUX1 are similar to those in Pax-3, Pax-7, OTX1, and OTX2.
DUX4 (also known as DUX10) can form homodimers and maps within the D4Z4 repeat unit implicated in Facioscapulohumeral muscular dystrophy (FSHD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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