Thermo Fisher Scientific c-Cbl Polyclonal Antibody
Thermo Fisher Scientific의 c-Cbl Polyclonal Antibody는 인간 시료에 반응하는 Rabbit IgG 기반 항체로, Western blot에 적합합니다. 합성 펩타이드(aa 580-630)를 면역원으로 사용하며, 액상 형태로 1 mg/mL 농도입니다. 세포 신호 조절 및 단백질 분해 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human C-CBL aa 580–630 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913298 |
Product Specific Information
- Positive Control: THP-1 cell lysates
- Subcellular Location: Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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