Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody
Apolipoprotein J 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 적합. Human 시료 반응성, 고순도 Affinity chromatography 정제, 안정적인 액상 형태로 연구용에 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human Clusterin (aa 350–449) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913296 |
Product Specific Information
- Positive Control: Hela cell lysate, SKBR-3 cell lysate, human tonsil tissue, human pancreas tissue, A549
- Subcellular Location: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Nucleus, Secreted
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). It does not require ATP and maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70.
Binding to cell surface receptors triggers internalization and degradation of the chaperone-client complex. Secreted isoform 1 protects cells against apoptosis and complement cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes to promote proteasomal degradation of target proteins, modulating NF-kappa-B activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms inhibit BAX-dependent cytochrome c release, thus suppressing apoptosis.
Plays a role in regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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