Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Control: Hela cell lysate, SKBR-3 cell lysate, human tonsil tissue, human pancreas tissue, A549
• Subcellular Location: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Nucleus, Secreted

Target Information

Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). It does not require ATP and maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70.
Binding to cell surface receptors triggers internalization and degradation of the chaperone-client complex. Secreted isoform 1 protects cells against apoptosis and complement cytolysis. Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes to promote proteasomal degradation of target proteins, modulating NF-kappa-B activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms inhibit BAX-dependent cytochrome c release, thus suppressing apoptosis.
Plays a role in regulation of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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