Thermo Fisher Scientific MUC1 Chimeric Recombinant Rabbit Monoclonal Antibody (HMFG2)
MUC1 종양 관련 항원을 인식하는 재조합 래빗 모노클로날 항체로, 인간 시료에 반응합니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific MUC1 Chimeric Recombinant Rabbit Monoclonal Antibody (HMFG2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
| ELISA | Assay-dependent |
| Immunomicroscopy (IM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HMFG2 |
| Immunogen | High-MW glycoprotein of the human milk fat globule |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074485 |
Product Specific Information
This antibody recognizes MUC1, a tumor-associated antigen expressed in more than 90% of ovarian carcinomas. The antigen is a high molecular weight (80,000–200,000) glycoprotein.
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through proteolysis and glycosylation steps.
MUC1 is highly polymorphic, with alleles encoding different numbers of tandem repeats (30–90), resulting in variable molecular weights.
It is abundantly expressed in >90% of breast carcinomas and metastases.
Overexpression, aberrant localization, and altered glycosylation of MUC1 are associated with carcinomas.
Multiple alternatively spliced transcript variants exist, with some full-length forms determined.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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