Thermo Fisher Scientific Adalimumab Recombinant Human Monoclonal Antibody (D2E7 (Adalimumab))
Adalimumab 기반의 인간 재조합 단클론 항체로 TNF-α에 특이적으로 결합. IHC, ICC, ELISA, 억제 분석 등 다양한 면역학적 실험에 사용 가능. HEK293 세포에서 발현된 IgG1, kappa 형식의 항체로 Protein A 정제. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | D2E7 (Adalimumab) |
| Immunogen | This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074490 |
Product Specific Information
Specificity: Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
Target Information
Adalimumab (Humira) is a humanized monoclonal antibody approved by the U.S. FDA for treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis.
Adalimumab binds to TNF-alpha and blocks its interaction with TNF-alpha receptors, thereby reducing the inflammatory response in autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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