Thermo Fisher Scientific Natalizumab Chimeric Recombinant Rabbit Monoclonal Antibody (Natalizumab)
Natalizumab 키메라 재조합 토끼 단클론 항체로, 인간 α4β1 및 α4β7 인테그린을 특이적으로 인식합니다. 유세포분석 및 억제 실험에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 연구용으로 다발성 경화증 및 크론병 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1 µg/mL |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Natalizumab |
| Immunogen | The RAMOS cell line, a non-EBV releasing cell line, injected into mice. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074489 |
Product Specific Information
Specificity: This antibody binds to the alpha 4 subunit of alpha-4Beta1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha-4Beta7 integrin.
Target Information
Natalizumab is a recombinant, humanized monoclonal antibody that binds to alpha4beta1 integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1).
It is used in research related to relapsing-remitting multiple sclerosis and Crohn’s disease.
Natalizumab was the first targeted therapy shown to block lymphocyte entry into the CNS, thereby preventing acute demyelinating relapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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