Thermo Fisher Scientific beta Amyloid Chimeric Recombinant Rabbit Monoclonal Antibody (6E10)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody binds specifically to amino acid residues 1–16 of beta amyloid.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), an aspartyl protease activated by prohormone convertase, furin. The resulting membrane-bound remnant is further processed by gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, and nicastrin, producing the amyloid beta peptide.

Abeta is an extracellular filamentous protein found in amyloid cores, neuritic plaques, and neurofibrillary tangles. Abnormal accumulation of beta amyloid is a hallmark of Alzheimer’s disease, as well as other conditions such as Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.