Thermo Fisher Scientific CD140b (PDGFRB) Monoclonal Antibody (APB5), APC, eBioscience
Mouse CD140b (PDGFRB) 단백질을 인식하는 APB5 클론 단일클론 항체로, APC 형광 표지되어 있음. Flow cytometry에 최적화되어 있으며 0.5 µg/test로 사용. PDGFRB의 발현 및 세포 신호 연구에 적합. 4°C 암조건 보관.
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Thermo Fisher Scientific CD140b (PDGFRB) Monoclonal Antibody (APB5), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 28 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Fish, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | APB5 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1548752 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- APC-eFluor 780
- Biotin
- Functional Grade
- PE
- PE-Cyanine7
- PE-eFluor 610
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation available
Product Specific Information
The APB5 monoclonal antibody reacts with the mouse CD140b molecule, the beta chain of the platelet-derived growth factor receptor (PDGFRB). PDGFRB is a receptor tyrosine kinase that forms dimers upon ligand binding and phosphorylates substrates. Dimers can be alpha/alpha, beta/beta, or alpha/beta heterodimers, serving as substrates for kinase activity. CD140b is expressed in embryonic tissues and mesenchymal-derived adult mouse cells. PDGFRB plays a significant role in the formation of fibrous atherosclerotic lesions.
Applications Reported: Flow cytometric analysis.
Applications Tested: Flow cytometric analysis of NIH 3T3 cells; ≤0.5 µg/test in 100 µL volume (10⁵–10⁸ cells/test). Antibody should be titrated for optimal performance.
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. It acts as a mitogen for mesenchymal-origin cells. The receptor forms homodimers or heterodimers depending on the bound growth factor. The PDGFRB gene is located on chromosome 5, adjacent to granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor genes, all potentially involved in 5-q syndrome. A translocation between chromosomes 5 and 12 fusing PDGFRB with ETV6 results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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