Thermo Fisher Scientific CD20 Monoclonal Antibody (LT20), APC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD20 (Bp35), a 33–37 kDa non-glycosylated membrane receptor with four transmembrane domains. CD20 is expressed on B lymphocytes (lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

Target Information

CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, some T lymphocytes, and follicular dendritic cells. It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. CD20 is associated with lipid rafts and participates in BCR signaling. It remains on the cell surface after antibody binding, making it a valuable target for therapeutic B-cell depletion.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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