Thermo Fisher Scientific CD20 Monoclonal Antibody (LT20), APC
인간 CD20 항원을 인식하는 LT20 클론 단일클론 항체로, APC 형광체가 결합된 제품입니다. Flow cytometry에 적합하며, B세포 표면 CD20 검출에 사용됩니다. 고순도 크로마토그래피로 정제되어 안정적이며 4°C 암소 보관이 필요합니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LT20 |
| Immunogen | Normal human lymphocytes from lymph node |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071554 |
Additional Formats
- Unconjugated
- Biotin
- FITC
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD20 (Bp35), a 33–37 kDa non-glycosylated membrane receptor with four transmembrane domains. CD20 is expressed on B lymphocytes (lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, some T lymphocytes, and follicular dendritic cells. It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation. CD20 is associated with lipid rafts and participates in BCR signaling. It remains on the cell surface after antibody binding, making it a valuable target for therapeutic B-cell depletion.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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