Thermo Fisher Scientific Atrophin 1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Atrophin 1. Recombinant protein control fragment (Product #RP-91651). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Atrophin 1,uniProtId:P54259-1,ncbiNodeId:9606,antigenRange:528-673,antigenLength:1190,antigenImageFileName:PA5-56799_Atrophin_1_P54259-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56799_Atrophin_1_P54259-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638390

Product Specific Information

Immunogen sequence: HPYAMSPSLG SLRPYPPGPA HLPPPHSQVS YSQAGPNGPP VSSSSNSSSS TSQGSYPCSH PSPSQGPQGA PYPFPPVPTV TTSSATLSTV IATVASSPAG YKTASPPGPP PYGKRAPSPG AYKTATPPGY KPGSPPSFRT GTPPGY

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

Target Information

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.