Thermo Fisher Scientific FOXRED2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FOXRED2. Recombinant protein control fragment (Product #RP-91545). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FOXRED2,uniProtId:Q8IWF2-1,ncbiNodeId:9606,antigenRange:34-170,antigenLength:684,antigenImageFileName:PA5-56797_FOXRED2_Q8IWF2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56797_FOXRED2_Q8IWF2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641724

Product Specific Information

Immunogen sequence: CVLGAGPAGL QMAYFLQRAG RDYAVFERAP RPGSFFTRYP RHRKLISINK RYTGKANAEF NLRHDWNSLL SHDPRLLFRH YSRAYFPDAR DMVRYLGDFA DTLGLRVQYN TTIAHVTLDK DRQAWNGHYF ILTDQKG

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.

Target Information

FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.