Thermo Fisher Scientific FOXRED2 Polyclonal Antibody
Human FOXRED2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. FOXRED2의 ERAD 관련 단백질 연구에 적합.
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- PA556797
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FOXRED2. Recombinant protein control fragment (Product #RP-91545). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641724 |
Product Specific Information
Immunogen sequence:
CVLGAGPAGL QMAYFLQRAG RDYAVFERAP RPGSFFTRYP RHRKLISINK RYTGKANAEF NLRHDWNSLL SHDPRLLFRH YSRAYFPDAR DMVRYLGDFA DTLGLRVQYN TTIAHVTLDK DRQAWNGHYF ILTDQKG
Sequence identity:
- Mouse: 87%
- Rat: 87%
Target Information
Protein: FOXRED2 (also known as ERFAD)
Function: Endoplasmic reticulum (ER) luminal flavoprotein involved in ER-associated degradation (ERAD). It binds non-native proteins in the ER and targets them to the ubiquitination machinery for degradation. Knockdown of FOXRED2 delays degradation of ERAD model substrates and decreases polyubiquitinated protein levels.
Clinical relevance: Related to FOXRED1, which is implicated in mitochondrial complex I deficiency (MT-C1D), suggesting FOXRED2 may also play a role in this condition.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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