Thermo Fisher Scientific Phospho-TGFBR1 (Ser165) Polyclonal Antibody
TGFBR1의 인산화된 Ser165 잔기를 인식하는 rabbit polyclonal antibody. Western blot에 최적화되어 있으며, 인간, 생쥐, 랫트 시료에 반응합니다. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TGFBR1 (Accession P36897), corresponding to amino acid residues around phosphorylated Ser165 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817217 |
Product Specific Information
This antibody detects endogenous levels of TGFBR1 only when phosphorylated at Ser165.
Target Information
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which includes ACVRs and BMPRs. Upon binding TGF-β, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation, leading to downstream phosphorylation of SMADs. TGFBR1 forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transmitting the signal from the cell surface to the cytoplasm. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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