Thermo Fisher Scientific Phospho-AHNAK (Ser5784) Polyclonal Antibody
Phospho-AHNAK (Ser5784) 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. 1 mg/mL 액상 형태로 제공되며, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AHNAK (Accession Q09666), corresponding to amino acid residues around phosphorylated Ser5784. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817221 |
Product Specific Information
This antibody detects endogenous levels of Desmoyokin only when phosphorylated at Ser5784.
Target Information
AHNAK1 (Desmoyokin) is a large (~700 kDa) scaffold protein that translocates to the plasma membrane after an increase in extracellular calcium level or upon protein kinase C activation. It regulates extracellular calcium influx mediated by L-type Ca²⁺ channels and is implicated in diverse signal transduction processes affecting cell differentiation and proliferation.
In response to calcium-dependent intercellular contacts, AHNAK1 forms multimeric complexes in the plasma membrane connected with actin and annexin 2/S100A10 assemblies, contributing to plasma membrane architecture.
In epithelial cells, AHNAK1 is localized in the cytoplasm or membrane-associated, whereas in nonepithelial cells, it is predominantly nuclear with weak DNA-binding activity and association with the DNA-ligase IV–XRCC4 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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