Thermo Fisher Scientific Estrogen Receptor (Marker of Estrogen Dependence) Monoclonal Antibody (AER311)
에스트로겐 수용체(ER) 검출용 단클론 항체로, 인간 및 동물 시료에서 ER 의존성 연구에 적합. ICC/IF, Flow Cytometry, Peptide Array 등 다양한 응용 가능. 단클론 항체(AER311), Mouse IgG2a isotype. 단백질 A/G 정제, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AER311 |
| Immunogen | ER purified from cow uterus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor functions as a ligand-activated transcription factor. Upon binding to estrogen, it undergoes a conformational change that enables dimerization and binding to estrogen response elements (ERE) in DNA. This interaction regulates gene transcription through coactivator or corepressor recruitment.
There are two main forms of the estrogen receptor, ERα (ESR1) and ERβ (ESR2). Alternative RNA splicing produces multiple ERα isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are expressed in many tissues, crucial for sexual development, reproduction, and bone physiology, and are implicated in diseases such as breast and endometrial cancers, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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