Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (rESR1/8761)
에스트로겐 수용체 알파(ERα)를 검출하는 마우스 단클론 항체로, 에스트로겐 의존성 마커 연구에 적합합니다. IHC(P) 및 IHC(PFA)에서 사용 가능하며, 고순도 Protein A/G 정제 제품입니다. 4°C 보관, 인간 시료 반응성.
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- 2099-MSM50-Px (2개 옵션)
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Applications and Tested Dilution
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rESR1/8761 |
| Immunogen | Recombinant fragment corresponding to C-terminus of human ER-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This interaction can regulate gene transcription through coactivator or corepressor recruitment.
There are two major forms of the estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. Alternative RNA splicing produces at least four known isoforms of ER-alpha (66, 53, 47, and 35 kDa). Estrogen receptors are widely expressed in various tissues, essential for sexual development and reproductive function, and also influence bone metabolism. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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