Thermo Fisher Scientific Estrogen Receptor (Marker of Estrogen Dependence) Monoclonal Antibody (AER311)
에스트로겐 수용체(ER)를 인식하는 단클론 항체로, 호르몬 의존성 연구에 적합. 인간, 마우스, 랫 등 다양한 종에 반응. ICC/IF, Flow Cytometry, Peptide Array에 사용 가능. 단백질 A/G 정제, 무보존제 PBS 용액 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AER311 |
| Immunogen | ER purified from cow uterus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. ER regulates gene transcription through coactivator or corepressor recruitment.
Two main forms exist: ER alpha (ESR1) and ER beta (ESR2). Alternative RNA splicing produces at least four ER-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). ERs are widely expressed in various tissues and are essential for sexual development, reproductive function, and bone physiology. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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