Thermo Fisher Scientific NGF Polyclonal Antibody

Thermo Fisher Scientific NGF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
After reconstitution, keep aliquots at -20°C for higher stability, and at 4°C with an appropriate antibacterial agent.
Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for additional stability.

Target Information

Nerve growth factor (NGF) influences the survival and differentiation of various neuronal and nonneuronal cells.
NGF binds to specific cell surface receptors with both high and low affinity sites, but only the high affinity form is capable of signal transduction.
Cross-linking studies with 125I-NGF show that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF, while the low affinity receptor forms an Mr 100,000 complex.
Full-length cDNA clones for human and rat NGF receptor genes reveal >90% homology between species.
NGF regulates growth and differentiation of sympathetic and sensory neurons and stimulates division of embryonic sensory neurons.
Mutations in the NGF gene are associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5), and dysregulation of NGF expression is linked to allergic rhinitis.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.

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