Thermo Fisher Scientific proBDNF Polyclonal Antibody
proBDNF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(F) 실험에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 합성 펩타이드 면역원으로 제작되었습니다. 연구용으로 사용되며 높은 특이성과 안정성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
- Publications: View 1 publication
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: 1–5 µg/mL
- Publications: None
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues C-E(69)LLDEDQKVRPNEE(82) of human BDNF precursor |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2243446 |
Product Specific Information
Reconstitute in 20 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, keep aliquots at -20°C for higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature 14 kDa protein, proBDNF is biologically active and secreted in synaptic vesicles along with the mature form.
BDNF is widely expressed in the central nervous system and acts on several classes of neurons via TrkB and p75-NTR receptors. It promotes neuronal survival and differentiation, playing a critical role in memory formation and synaptic regulation. Expression of BDNF is reduced in Alzheimer’s and Huntington’s disease patients and may influence stress response and mood disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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