Thermo Fisher Scientific SR-BI/SR-BII Polyclonal Antibody
SR-BI/SR-BII 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. HDL 관련 콜레스테롤 대사 연구에 적합.
- 카탈로그번호
- PA316805
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SR-BI/SR-BII Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 | - |
| Flow Cytometry (Flow) | 1:400 | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Neutralization (Neu) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Extracellular residues 230–380 of Scavenger Receptor-BI/BII expressed as two tandem copies in bacteria using the pET system |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2182692 |
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene.
SR-BII and SR-BI are identical except for the encoded C-terminal cytoplasmic domain. Both bind HDL and mediate selective uptake of HDL cholesteryl ester, but SR-BII has approximately 4-fold lower efficiency than SR-BI.
SR-BI and SR-BII are expressed primarily in liver and non-placental steroidogenic tissues. Although the roles of these scavenger receptors are not fully defined, SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, with both isoforms mediating selective lipid transfer between HDL and cells.
The relative expression and functional activities of these isoforms provide a potential mechanism for regulating selective lipid transfer between HDL and cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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