Thermo Fisher Scientific LIMP2 Polyclonal Antibody
LIMP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. Dog, Human, Mouse 등 여러 종에 반응하며 whole serum 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 | - |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A C-terminal synthetic peptide made to the mouse LIMPII/lgp85 protein sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2182836 |
Product Specific Information
Suggested positive control: 3T3 whole cell lysate
Target Information
High-density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk of atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene.
SR-BII differs from SR-BI in the encoded C-terminal cytoplasmic domain, which is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately four-fold lower efficiency than SR-BI.
SR-BII is abundant in mouse tissues expressing SR-BI, including liver, adrenal glands, and testes. Although its role is not completely clear, SR-BII may function as an HDL receptor. SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, mediating selective lipid transfer between HDL and cells. The relative expression and functional activities of these isoforms provide a potential means of regulating lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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