Thermo Fisher Scientific PLAT Polyclonal Antibody, MaxPab
Human PLAT(tPA) 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합. Affinity chromatography로 정제된 액상 항체이며 PBS buffer에 보존. 조직 재형성 및 세포 이동 관련 연구용으로 사용 가능.
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Thermo Fisher Scientific PLAT Polyclonal Antibody, MaxPab
Applications
- Western Blot (WB)
Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | PLAT (NP_000921.1, 1–562 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK DVPGVYTKVT NYLDWIRDNM RP
Target Information
TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. It plays an essential role in tissue remodeling, degradation, and cell migration. TPA binds fibrin with high affinity, enhancing catalytic efficiency up to 1000-fold. It also interacts with heparin, laminin, fibronectin, mannose receptor, and LRP1, influencing plasminogen activation and clearance. Additional interactions with annexin II and cytokeratin 8 are known. Binding to vascular smooth muscle cells (VSMC) reduces TPA inhibition by PAI-1 significantly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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