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Thermo Fisher Scientific Phospho-ERK1/ERK2 (Thr185, Tyr187) Polyclonal Antibody
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Phospho-ERK1/ERK2 (Thr185, Tyr187) 항체로 다양한 종에서 반응하며, Western blot 및 IHC에 적합. 인산화된 ERK1/2 특이적 인식. 항원 친화 크로마토그래피로 정제된 rabbit polyclonal 항체. 연구용으로만 사용.
- 카탈로그번호
- 44680G
- 판매단위
- pk
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마지막 업데이트 2025. 08. 04. 오후 03:06
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Thermo Fisher Scientific 44680G Phospho-ERK1/ERK2 (Thr185, Tyr187) Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
617,800원VAT 포함 679,580원
Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-ERK1/ERK2 (Thr185, Tyr187) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 56 publications |
| Immunohistochemistry (IHC) | - | View 7 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | View 2 publications |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 6 publications |
| Miscellaneous PubMed (Misc) | - | View 4 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, C. elegans, Chicken, Fruit fly, Human, Mouse, Rat, Xenopus |
| Published Species | C. elegans, Dog, Human, Mouse, Pig, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human ERK1&2 region containing threonine 202/185 and tyrosine 204/187. Conserved among rat, mouse, cow, frog, snail, nematode, and fruit fly. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533719 |
Product Specific Information
- Purified from rabbit serum by sequential epitope-specific chromatography.
- Contains enough material for 10 mini-blots.
- Antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to phosphorylation sites to remove cross-reactivity with non-phosphorylated ERK1&2.
- Final product generated by affinity chromatography using ERK1&2-derived peptide phosphorylated at Thr202/185 and Tyr204/187.
- Validated for western blotting and immunostaining; other applications may require optimization.
- Positive controls: PC12 cells ± Sorbitol; NIH3T3 ± PDGF; HEK293 ± UV.
Target Information
ERK1 and ERK2 are key kinases involved in meiosis, mitosis, and postmitotic cellular functions. They are activated by diverse stimuli such as growth factors, cytokines, viral infection, and GPCR ligands. Upon activation, Raf phosphorylates MEK1/2, which in turn phosphorylates ERK1/2 at specific threonine and tyrosine residues. Activated ERKs regulate cytoplasmic targets or translocate to the nucleus to activate transcription factors like c-Fos and Elk-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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