Thermo Fisher Scientific INSR Polyclonal Antibody
Western blot 및 IHC(P)에서 사용 가능한 INSR 폴리클로날 항체. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 단기 4°C, 장기 -20°C 보관. 인슐린 수용체 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 939–1347 of Human Insulin Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.31 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2544810 |
Product Specific Information
- Recommended positive controls: 293T, NIH-3T3, PC-12, rat liver
- Predicted reactivity: Mouse (95%), Rat (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
INSR (Insulin Receptor) is a receptor tyrosine kinase that mediates the effects of insulin. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarities. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR.
In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, and IGF-1R defects may also cause certain forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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