Thermo Fisher Scientific Phospho-PAK5/PAK6 (Ser602, Ser560) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of Serine 602/560(R-K-S(p)-L-V) derived from Human PAK5/6. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PAK5/PAK6,uniProtId:Q9NQU5-1,ncbiNodeId:9606,antigenRange:558-562|600-604,antigenLength:681,antigenImageFileName:PA5-37827_PAK5PAK6_Q9NQU5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37827_PAK5PAK6_Q9NQU5-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:PAK5/PAK6,uniProtId:Q9P286-1,ncbiNodeId:9606,antigenRange:558-562|600-604,antigenLength:719,antigenImageFileName:PA5-37827_PAK5PAK6_Q9P286-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37827_PAK5PAK6_Q9P286-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2554435

Product Specific Information

A suggested positive control for Western blot is HeLa cells.

Target Information

PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction.PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.