Thermo Fisher Scientific Phospho-Synaptotagmin 1/2 (Thr202, Thr199) Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:100-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of threonine 202/199 (R-K-T(p)-L-N) derived from Human Synaptotagmin 1/2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Synaptotagmin 1/2,uniProtId:P21579-1,ncbiNodeId:9606,antigenRange:199-202|200-204,antigenLength:422,antigenImageFileName:PA5-37830_Synaptotagmin_12_P21579-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37830_Synaptotagmin_12_P21579-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:Synaptotagmin 1/2,uniProtId:Q8N9I0-1,ncbiNodeId:9606,antigenRange:197-201|199-202,antigenLength:419,antigenImageFileName:PA5-37830_Synaptotagmin_12_Q8N9I0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37830_Synaptotagmin_12_Q8N9I0-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2554438

Product Specific Information

A suggested positive control for ICC/IF is Hela cells.

Target Information

Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.