Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (16A11)

Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (16A11)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-20112 detects cardiac troponin I in human, mouse, rat, bovine, feline, canine, goat, porcine, and rabbit samples.

Target Information

Cardiac Troponin I (also known as cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms a complex with troponin C (TnC) and troponin T (TnT).
The TnT subunit binds to tropomyosin to form a troponin-tropomyosin complex anchored by the binding of TnI to actin within muscle thin filaments.
Calcium binding to TnC induces structural changes that release the inhibitory region of TnI from actin, allowing myosin attachment and muscle contraction.
Blood levels of TnI and TnT serve as diagnostic indicators of cardiac muscle damage and help differentiate angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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