Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (16A11)
Cardiac Troponin I 단백질을 인식하는 mouse monoclonal antibody (clone 16A11). 다양한 종에서 반응하며 WB, IHC, ELISA 등에 사용 가능. Protein A 정제, 5.2 mg/mL 농도, 액상형, 연구용 전용.
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Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (16A11)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 2 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 4 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| ELISA | Assay-dependent | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Affinity Purification (AP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Cat, Goat, Human, Mouse, Pig, Rabbit, Rat |
| Published Species | Chicken, Human, Zebrafish |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16A11 |
| Immunogen | Full length, human cardiac troponin I protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561823 |
Product Specific Information
MA1-20112 detects cardiac troponin I in human, mouse, rat, bovine, feline, canine, goat, porcine, and rabbit samples.
Target Information
Cardiac Troponin I (also known as cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms a complex with troponin C (TnC) and troponin T (TnT).
The TnT subunit binds to tropomyosin to form a troponin-tropomyosin complex anchored by the binding of TnI to actin within muscle thin filaments.
Calcium binding to TnC induces structural changes that release the inhibitory region of TnI from actin, allowing myosin attachment and muscle contraction.
Blood levels of TnI and TnT serve as diagnostic indicators of cardiac muscle damage and help differentiate angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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