
Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (16A12)
Cardiac Troponin I 단백질을 인식하는 mouse monoclonal antibody (clone 16A12). Western blot, IHC, IP, AP 등 다양한 assay에 사용 가능. Protein A로 정제된 액상형 항체로, 7.7 mg/mL 농도이며 인간 시료에서 cardiac troponin I 검출에 적합.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
- Affinity Purification (AP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16A12 |
| Immunogen | Full length, human cardiac troponin I protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7.7 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561832 |
Product Specific Information
MA1-20113 detects cardiac troponin I in human samples.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms a complex with troponin C (TnC) and troponin T (TnT).
The TnT subunit binds to tropomyosin, forming a troponin-tropomyosin complex anchored by TnI binding to actin within muscle thin filaments.
Calcium binding to the regulatory TnC subunit releases the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of cardiac muscle damage, differentiating angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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