Thermo Fisher Scientific Phospho-CDK7 (Ser164) Polyclonal Antibody
CDK7의 Ser164 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 정제 및 안정적인 PBS/glycerol 저장 buffer 구성. 인체, 생쥐, 랫트 반응성.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK7 (Accession P50613), corresponding to amino acid residues around phosphorylated Ser164 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817011 |
Product Specific Information
Antibody detects endogenous levels of CDK7 only when phosphorylated at Ser164.
Target Information
The trimeric complex of CDK7, cyclin H, and MNAT1 functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, involved in transcription initiation and DNA repair. This complex links transcription regulation and the cell cycle. The CDK7-bound complex plays a role in BRCA1-mediated double-strand break repair and may be a target of germline cancer-inducing mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-105583_CDK7_P50613-1_Rabbit.svg)
(이미지: PA5-105583_CDK7_P50613-1_Rabbit_PDP.jpeg)
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