Thermo Fisher Scientific Phospho-CDK9 (Ser347) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of CDK9 only when phosphorylated at Ser347.

Target Information

CDK9 is a serine/threonine kinase which, when complexed with Cyclin T1, forms an active holoenzyme complex that plays a key role in regulating the eukaryotic cell cycle. It is coexpressed and copurified with Cyclin T1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity toward the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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