Thermo Fisher Scientific Phospho-CDK9 (Ser347) Polyclonal Antibody
CDK9 단백질의 Ser347 위치에서 인산화된 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P) 실험에 적합하며, 인간·마우스·랫트 시료에서 반응. 고순도 정제 및 안정한 PBS/glycerol 저장 조건 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK9 (Accession P50750), corresponding to amino acid residues around phosphorylated Ser347 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817012 |
Product Specific Information
This antibody detects endogenous levels of CDK9 only when phosphorylated at Ser347.
Target Information
CDK9 is a serine/threonine kinase which, when complexed with Cyclin T1, forms an active holoenzyme complex that plays a key role in regulating the eukaryotic cell cycle. It is coexpressed and copurified with Cyclin T1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity toward the CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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