Thermo Fisher Scientific FGFR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL EALEERPAVM TSPLYLEIII YCTGAFLISC MVGSVIVYKM K
• Positive Samples: Mouse brain
• Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic vesicle, Nucleus
• Protein Type: Single-pass type I membrane protein, cytosol

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family, which includes FGFR1–FGFR4. These receptors are membrane-spanning tyrosine kinases that serve as high-affinity receptors for 17 fibroblast growth factors (FGF1–FGF17).
The FGF receptor family plays critical roles in mesoderm induction, patterning, cell growth and migration, organogenesis, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed differently during embryonic and adult stages. Mutations or defects in FGFR1 are associated with several diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, and others.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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