Thermo Fisher Scientific Ido Polyclonal Antibody
IDO 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, ELISA, IP에 사용 가능. Mouse IDO에 반응하며, 액상 형태(1 mg/mL)로 제공. 고순도 친화 크로마토그래피로 정제되어 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IDO affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of mouse IDO. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 1mg/mL BSA, 50% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
- A BLAST analysis suggests cross-reactivity with mouse based on 100% sequence homology.
- Cross-reactivity with IDO from other sources has not been determined.
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of regulatory molecules such as tryptophan, serotonin, and melatonin. This process produces biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) trigger IDO1 induction, contributing to antimicrobial defense by degrading tryptophan and inhibiting pathogen growth.
IDO1 also plays a critical role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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