Thermo Fisher Scientific Phospho-PI3K p85/p55 (Tyr458, Tyr199) Recombinant Rabbit Monoclonal Antibody (PI3KY458-1A11), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 5 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• Request custom conjugation

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the large rabbit immune repertoire

Target Information

Phosphoinositide 3-kinase (PI3K, phospho PI3K) binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain, acting as an adapter mediating the association of the p110 catalytic unit to the plasma membrane.
Phospho PI3K is essential for insulin-stimulated glucose uptake and glycogen synthesis in insulin-sensitive tissues. It also binds to IRS-1 upon insulin stimulation. Growth factors and hormones trigger this phosphorylation event, coordinating cell growth, cell cycle entry, migration, and survival.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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