Thermo Fisher Scientific TAOK1 Recombinant Rabbit Monoclonal Antibody (1H3L17)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Cat, and Bovine.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone the specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.

Advantages:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to large rabbit immune repertoire

Target Information

TAOK1 (TAO kinase 1) is a serine/threonine-protein kinase involved in the regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs).

It activates and binds to MEK3, implicating TAOK1 in the regulation of the p38 MAPK pathway. TAOK1 (also known as MARKK) is a microtubule affinity-regulating kinase that plays a key role in mitotic progression, chromosome congression, and checkpoint-induced anaphase delay.

Biological functions:

• Regulates p38/MAPK14 stress-activated MAPK cascade
• Participates in DNA damage response and cytoskeleton stability regulation
• Phosphorylates MAP2K3, MAP2K6, and MARK2
• Acts as an activator of the p38/MAPK cascade via MAP2K3 and MAP2K6 phosphorylation
• Involved in G-protein coupled receptor signaling to p38/MAPK14
• Functions in G2/M transition DNA damage checkpoint activation

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.