Thermo Fisher Scientific WWC1 Recombinant Rabbit Monoclonal Antibody (1H4L22)
WWC1 단백질을 인식하는 재조합 토끼 단클론 항체로, ICC/IF에 사용 가능. 인간에 반응하며 원숭이, 개, 돼지에도 예측 반응. 높은 특이성과 재현성을 제공하며, 단백질 A로 정제된 액상 항체. 연구용으로 Hippo 신호 경로 관련 연구에 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H4L22 |
| Immunogen | Protein corresponding to human WWC1 (aa772-aa851) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2762386 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, and Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway.
This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis.
WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2.
It acts as a transcriptional coactivator of ESR1, which plays an essential role in DYNLL1-mediated ESR1 transactivation.
WWC1 also functions as a regulator of collagen-stimulated activation of the ERK/MAPK cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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