Thermo Fisher Scientific STING Recombinant Rabbit Monoclonal Antibody (2H1L5)
STING 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체(2H1L5). Western blot, IHC, ICC/IF에 적합하며 높은 특이성과 재현성을 제공. Expi293 시스템에서 생산된 비결합형 항체로, PBS 용액 내 0.5 mg/mL 농도로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2H1L5 |
| Immunogen | Protein corresponding to human STING [aa139–aa379] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2762404 |
Product Specific Information
This antibody is predicted to react with Monkey, Goat, and Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
STING is a 379-amino-acid signaling protein that plays a crucial role in innate immune signaling. It activates NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferons (IFN-alpha and IFN-beta), establishing a potent antiviral state.
STING may also be involved in:
- Translocon function influencing type I interferon induction
- Transduction of apoptotic signals via MHC-II association
- Detection of intracellular viral RNA and B-form DNA
- Mediating death signaling through ERK pathway activation
Localization: endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane.
Expression: ubiquitous across most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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