Thermo Fisher Scientific Relaxin 3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human mature Relaxin-3 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Relaxin 3 is a member of the Relaxin-like peptide family involved in neuropeptide signaling. It serves as a ligand for human Relaxin receptors 3 and 4, both G protein-coupled receptors. The highest expression of Relaxin 3 occurs in the brain, particularly in the pons/medulla region, with notable presence in the hippocampus and olfactory areas. Additional expression is found in the spleen, thymus, lung, and ovary. Relaxin 3 inhibits forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells expressing Relaxin receptor 3. Repeated administration of Relaxin 3 reduces plasma thyroid-stimulating hormone levels, indicating a potential role in long-term regulation of food intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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