Thermo Fisher Scientific ATRX Monoclonal Antibody (GT4212)
ATRX 단백질을 표적으로 하는 Thermo Fisher Scientific의 GT4212 단클론 항체로, Western blot과 Immunocytochemistry에 적합합니다. 인간 및 생쥐 반응성이 있으며, Protein G로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT4212 |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735128 |
Product Specific Information
- Positive Control: 293T, Neuro2A, C8D30, BCL-1
- Predicted Reactivity: Chimpanzee (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ATRX encodes a protein that contains an ATPase/helicase domain, belonging to the SWI/SNF family of chromatin remodeling proteins. Mutations in this gene are associated with X-linked mental retardation (XLMR) often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations can alter DNA methylation patterns, linking chromatin remodeling, DNA methylation, and gene expression in development. The protein undergoes cell cycle-dependent phosphorylation, regulating its nuclear matrix and chromatin association, suggesting a role in gene regulation during interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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