Thermo Fisher Scientific BMP-8B Monoclonal Antibody (GT1017)
Human BMP-8B 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, WB 및 ICC/IF에 최적화되어 있습니다. 단백질 G로 정제된 액상 형태이며, 1.0 mg/mL 농도로 제공됩니다. 연구용으로 사용되며, BMP-8B 관련 신호전달 및 발현 연구에 적합합니다.
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Thermo Fisher Scientific BMP-8B Monoclonal Antibody (GT1017)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT1017 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human BMP8b. (Exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735130 |
Product Specific Information
- Positive Control: human BMP8B-transfected 293T cells
- Predicted Reactivity: Human (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BMP-8B encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors, leading to recruitment and activation of SMAD family transcription factors that regulate gene expression.
The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer.
BMP-8B may have arisen from a gene duplication event, and its gene duplicate is also present on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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