Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI7G9), TrueMAB
HDAC9 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화됨. Human 시료에 반응하며, 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol buffer에 보존되어 안정적. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7G9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 181–460 of human HDAC9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, and acetylation of nucleosomal histones plays a key role in this process. Acetylation of lysine residues in histone tails induces conformational changes that increase DNA accessibility to transcription factors.
Several mammalian proteins act as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and TFIID subunit TAF II p250. Conversely, histone deacetylation is linked to transcriptional silencing. The histone deacetylase (HDAC) family includes HDAC1–9. HDAC9 and HDAC9a are alternatively spliced isoforms; HDAC9a is 132 amino acids shorter but retains catalytic activity and represses myocyte enhancer-binding factor 2-mediated transcription. Both isoforms are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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