Thermo Fisher Scientific RGMA Polyclonal Antibody
인간 RGMA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. WB와 IHC에 사용 가능하며, 합성 펩타이드 항원을 기반으로 제작되었습니다. 연구용으로만 사용되며, 신경계 발달 및 신호전달 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
- Publications: 참고 문헌 보기
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: 참고 문헌 보기
Miscellaneous PubMed (Misc)
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of mature human Repulsive Guidance Molecule A (RGMA) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: RGMA.
Target Information
RGMA is a member of the repulsive guidance molecule (RGM) family involved in multiple functions in the developing and adult nervous system. It regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and contributes to mature synapse formation.
RGMA binding to its receptor NEO1/neogenin activates the RHOA-ROCK1/Rho-kinase signaling pathway via the UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to neuronal growth cone collapse and neurite outgrowth inhibition.
Additionally, RGMA-NEO1 interaction influences HRAS-PTK2/FAK1-AKT1 signaling, resulting in HRAS inactivation.
RGMA also functions as a bone morphogenetic protein (BMP) coreceptor signaling through SMAD1, SMAD5, and SMAD8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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