Thermo Fisher Scientific PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (JF09-71)
PGC1 alpha/beta 인식용 재조합 토끼 단클론 항체로 Western blot에 적합합니다. HEK293 세포에서 발현되며 높은 특이도와 재현성을 제공합니다. Protein A로 정제된 액상 형태이며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
- Western Blot (WB): 1:500–1:2000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF09-71 |
| Immunogen | Synthetic peptide within human PGC1 alpha aa 755–798 and aa 269–323 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809840 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
PGC-1 beta is a tissue-specific co-activator that enhances the activity of estrogen receptor alpha. Its co-activation function depends on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner.
Ectopic expression of this protein increases mitochondrial number and basal oxygen consumption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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