Thermo Fisher Scientific Cytokeratin 14/16 Polyclonal Antibody
Cytokeratin 14/16을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 52 kDa 단백질 검출, >95% 순도. 피부 질환 연구 및 세포 구조 단백질 분석에 적합. 1 mg/mL 농도, 액상 형태로 4°C 또는 -20°C 보관.
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Thermo Fisher Scientific Cytokeratin 14/16 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus of human Cytokeratin 14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2553350 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 52 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bullosa simplex, an inherited skin disorder characterized by skin blistering due to basal keratinocyte fragility.
Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK), and unilateral palmoplantar verrucous nevus (UPVN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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