Thermo Fisher Scientific LIMK1/LIMK2 Polyclonal Antibody
LIMK1/LIMK2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(Paraffin)에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%) 보장. 세포 이동성과 형태형성 연구에 유용.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 380–420 of human LIMK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553351 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 72 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Proteins containing LIM motifs are typically involved in cell fate determination and growth control. LIM kinases (LIMK-1 and LIMK-2) regulate F-actin stabilization and cofilin activity, influencing cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest distinct roles during development. A truncated LIMK-2 form has been identified in adult testis, likely arising from alternative exon usage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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