Thermo Fisher Scientific NRG1 Polyclonal Antibody
NRG1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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- PA536057
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminal of human Neuregulin-1/SMDF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553348 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 44 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Neuregulin 1 (NRG1) was originally identified as a 44-kDa glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.
A variety of isoforms are produced from the NRG1 gene by alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms are tissue-specifically expressed and differ in structure. HRG isoforms contain immunoglobulin (Ig) and EGF-like domains; GGF isoforms include kringle-like, Ig, and EGF-like domains; SMDF isoform shares only the EGF-like domain.
All NRG1 isoforms interact with ERBB family tyrosine kinase receptors to induce growth and differentiation of epithelial, neuronal, glial, and other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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